Differences in the Levels of Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1ra) in Children with Status Epilepticus and Febrile Seizure
DOI:
https://doi.org/10.11594/jtls.07.03.05Keywords:
Febrile seizure, IL-1β, IL-1ra, status epilepticus.Abstract
Proinflammatory cytokines are elevated in status epilepticus and febrile seizure and associated with tissue damage. This study aimed to investigate the differences in interleukin 1 beta (IL-1β) and interleukin 1 receptor agonist (IL-1ra) levels in status epilepticus as compared with febrile seizure and febrile. This cross-sectional study was designed to include 45 subjects divided equally into three groups (status epilepticus, febrile seizure, and febrile). Both IL-1β and IL-1ra were measured by using an ELISA method. Results showed that IL-1β levels were significantly higher in the status epilepticus group as compared with the febrile seizure and febrile groups (p < 0.05). IL-1ra levels in the status epilepticus group were significantly lower compared with the febrile seizure group (p = 0.04). Consistently, the IL-1β/IL-1ra ratio in the status epilepticus group was significantly higher as compared with the febrile seizure group (p = 0.01). We concluded that IL-1β and the IL-1β/IL-1ra ratio were significantly higher in status epilepticus. IL-1ra levels were significantly higher in the febrile seizure group.
References
Rijkers K, Majoie HJ, Hoogland G et al. (2009) The role of interleukin-1 in seizure and epilepsy: A critical review. Ex-perimental Neurology 216 (2): 258-271. 258-71. doi: 10.1016/j.expneurol.2008.12.014.
Yu N, Di Q, Hu Y et al. (2012) A meta-analysis of pro-inflammatory cytokines in the plasma of epileptic patients with recent seizure. Neuroscience Letters 514 (1): 110-115. doi: 10.1016/j.neulet.2012.02.070.
Riviello JJ, Ashwal S, Hirtz D et al. (2006) Practice param-eter: diagnostic assessment of the child with status epilepti-cus (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neu-rology Society. Neurology 67 (9): 1542-1550.
Pusponegoro HD (2004) Kejang demam patofisiologi dan penatalaksanaannya. In: Kustiowati E, ed. Kumpulan ma-kalah pertemuan nasional – I epilepsi. Semarang, Penerbit UNDIP.
Johnston MV (2007) Seizures in childhood. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson textbook of pediatrics. 18th ed. WB Saunders Co., Philadelphia, pp 2457-2471.
Johnson EA, Kan RK (2010) The acute phase response and soman induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations. Journal of Neuroinflammation 7 (40): 1-9. doi: 10.1186/1742-2094-7-40.
Fernandes D, Pereira J, Silvestre J, Bento L (2014) Acute bacterial meningitis in the intensive care unit and risk fac-tors for clinical outcomes: Retrospective study. Journal of Critical Care 29 (3): 347-350. doi: 10.1016/j.jcrc.2013.12.
Uludag IF, Bilgin S, Zorlu Y et al. (2013) Interleukin-6, interleukin-1 beta, interleukin-1 receptor antagonist levels in epileptic seizure. Seizure 22 (6): 457-461. doi: 10.1016/j.sei
zure.2013.03.004.
Choi J, Koh S (2008) Role of brain inflammation in epilep-togenesis. Yonsei Medical Journal 49 (1): 1-18. doi: 10.3349/ymj.2008.49.1.1.
Barichello T, Generoso J, Collodel A et al. (2012) Patho-physiology of acute meningitis caused by Streptococcus pneumoniae and adjunctive therapy approaches Arquivos de Neuro-Psiquiatria 70 (5): 366-372. 10.1590/S0004-282X2012000500011.
Griffiths M, Mong HO, Wong SC et al. (2012) In Enterovi-rus 71 encephalitis with cardio-respiratory compromise, el-evated Interleukin -1β, interleukin 1 receptor antagonist, and granulocyte colony stimulating factor levels are marker of poor prognosis. The Journal of Infectius Diseases 206 (6): 881-892. doi: 10.1093/infdis/jis446.
Dube CM, Vezzani A, Behrens M (2005) Interleukin-1 beta contributes to the generation of experimental febrile seizures. Annals of Neurology 57 (1): 152– 155. doi: 10.1002/ana.20358.
Zhang S, Xu M, Jun Li, Ding S (2015) Immunologic char-acterization of Cytokine responses to enterovirus 71 and Coxsackievirus A16 infection in children. Medicine (Bal-timore) 94 (27): e1137. doi: 10.1097/MD.0000000000001137.
Scheld WM, Koedel U, Nathan B, Pfister HW (2002) Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury. The Journal of Infectious Diseases 186 (Suppl 2): S225-S233. doi: 10.1086/344939
Virta M, Hurme M, Helminen M (2002) Increased plasma level of pro and antiinflamatory cytokines in patients with febrile seizures. Epilepsia 43 (8): 920-923.
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